Publications | Thomas Lab

2023 (2 publications)

2D antiscatter grid and scatter sampling based CBCT method for online dose calculations during CBCT guided radiation therapy of pelvis

F Bayat, B Miller, Y Park, Z Yu, T Alexeev, D Thomas, K Stuhr, M Miften, C Altunbas

Medical Physics20234 citations

CBCT

Dose Calculation

Radiation Therapy

Computer Vision assisted Collision Avoidance for Radiation Therapy

David Thomas, Moyed Miften, Brian Kavanagh, Bernard Trip Jones

2023

Computer Vision

Collision Avoidance

View Publication

2022 (1 publications)

Multi-Institutional Study to Demonstrate An Increase in Variability of Delivered Dose to Patients for SRS Treatments as a Result of Dosimetric Leaf Gap Parameter Tuning

A Santoso, O Blasi, R Popple, S Holmes, K Woods, Y Vinogradskiy, D Thomas

MEDICAL PHYSICS, vol. 49 (6), pp. E361-E3612022

SRS

Dosimetry

Treatment Planning

2021 (1 publications)

Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy

Farnoush Forghani, Taylor Patton, Jennifer Kwak, David Thomas, Quentin Diot, Chad Rusthoven, Richard Castillo, Edward Castillo, Inga Grills, Thomas Guerrero, others

Radiotherapy and Oncology, vol. 160, Elsevier, pp. 120--124202110 citations

SPECT

Lung Cancer

Radiotherapy

2020 (7 publications)

Simulation of x-ray-induced acoustic imaging for absolute dosimetry: Accuracy of image reconstruction methods

Farnoush Forghani, Adam Mahl, Taylor J Patton, Bernard L Jones, Mark A Borden, David C Westerly, Cem Altunbas, Moyed Miften, David Thomas

Medical Physics, vol. 47, Wiley Online Library, pp. 1280--1290202025 citations

X-ray

Acoustic Imaging

Dosimetry

Deep Learning approach for automatic detection and identification of patient positioning devices for radiation therapy

David Thomas, Leah K Schubert, Yevgeniy Vinogradskiy, Sameer Nath, Brian Kavanagh, Moyed Miften, Bernard Jones

Medical Physics, Wiley Online Library2020

Deep Learning

Patient Positioning

Radiation Therapy

Integration of automation into an existing clinical workflow to improve efficiency and reduce errors in the manual treatment planning process for total body irradiation (TBI)

David Thomas, Brian Miller, Rachel Rabinovitch, Sarah Milgrom, Brian Kavanagh, Quentin Diot, Moyed Miften, Leah K Schubert

Journal of Applied Clinical Medical Physics, Wiley Online Library20204 citations

Automation

Treatment Planning

TBI

Effect of X-Ray Irradiation On the Ultrasound Imaging Signal of a Novel Photoacoustic Contrast Agent

F Forghani, A Mahl, G Shakya, M Borden, T Patton, Y Vinogradskiy, B Jones, M Miften, D Thomas

MEDICAL PHYSICS, vol. 47, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, pp. E763--E7632020

X-ray

Ultrasound

Photoacoustic

Lung Functional Avoidance Radiotherapy: Characterizing Spatial Differences Between Ventilation and Perfusion

F Forghani, T Patton, D Thomas, Q Diot, C Rusthoven, R Castillo, E Castillo, I Grills, T Guerrero, M Miften, others

MEDICAL PHYSICS, vol. 47, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, pp. E370--E3702020

Lung

Radiotherapy

Ventilation

Analysis of experimental acoustic waves induced by high energy pulsed X-ray beams

Farnoush Forghani, Adam Mahl, Bernard Jones, Mark Borden, Moyed Miften, David Thomas

Bulletin of the American Physical Society, vol. 65, APS2020

X-ray

Acoustic Waves

A fast and effective denoising solution using deep learning for real time X-ray Acoustic Computed Tomography

David Thomas, Farnoush Forghani, Adam Mahl, Bernard Jones, Mark Borden, Moyed Miften

Bulletin of the American Physical Society, vol. 65, APS2020

Deep Learning

X-ray

Acoustic CT

2019 (5 publications)

The current state of physics plan review training in medical physics residency programs in North America

Leah K Schubert, Kristi Hendrickson, Moyed Miften, Monica McNulty, Yevgeniy Y Vinogradskiy, David Thomas, David Westerly, Kelly Stuhr, Janet Corral, Danielle Royer

Practical radiation oncology, Elsevier20196 citations

Medical Physics

Education

Plan Review

Safety-oriented design of in-house software for new techniques: A case study using a model-based 4 DCT protocol

Dylan O'Connell, David Thomas, John H Lewis, Katelyn Hasse, Anand Santhanam, James M Lamb, Minsong Cao, Stephen Tenn, Nzhde Agazaryan, Percy P Lee, others

Medical physics, vol. 46, Wiley Online Library, pp. 1523--153220193 citations

Software Design

4DCT

Safety

An Analysis of X-Ray Induced Acoustic Imaging and Its Accuracy for Absolute Dosimetry

F Forghani, D Thomas

MEDICAL PHYSICS, vol. 46, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, pp. E412--E4132019

X-ray

Acoustic Imaging

Dosimetry

Clinical Introduction of 5DCT Simulation for Lung Cancer

M Lauria, D O'Connell, N Agazaryan, J Lewis, J Lamb, D Thomas, P Lee, D Low

MEDICAL PHYSICS, vol. 46, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, pp. E521--E5222019

5DCT

Lung Cancer

Simulation

An Efficient Workflow for Generation and Refinement of a Knowledge Based Planning Model for Pancreas SBRT Using Automation

T Patton, Q Diot, B Jones, L Olsen, Y Vinogradskiy, K Goodman, T Schefter, D Thomas

MEDICAL PHYSICS, vol. 46, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, pp. E367--E3672019

Knowledge Based Planning

Pancreas

SBRT

2018 (4 publications)

Initial clinical observations of intra-and interfractional motion variation in MR-guided lung SBRT

David Thomas, A Santhanam, AU Kishan, M Cao, J Lamb, Y Min, D O'Connell, Y Yang, N Agazaryan, PP Lee

The British journal of radiology, vol. 91, pp. 20170522201866 citations

MR-guided

Lung SBRT

Motion Variation

The effect of resonance on transient microbubble acoustic response: Experimental observations and numerical simulations

K Efthymiou, N Pelekasis, MB Butler, David Thomas, V Sboros

The Journal of the Acoustical Society of America, vol. 143, ASA, pp. 1392--1406201812 citations

Microbubble

Acoustics

Simulation

Model-Interpolated Gating for Magnetic Resonance Image–Guided Radiation Therapy

JS Ginn, D O'Connell, David Thomas, DA Low, JM Lamb

International Journal of Radiation Oncology* Biology* Physics, vol. 102, pp. 885-894201815 citations

MRI-guided

Radiation Therapy

Gating

Dependence of subject-specific parameters for a fast helical CT respiratory motion model on breathing rate: an animal study

D O'Connell, David Thomas, JM Lamb, JH Lewis, T Dou, JP Sieren, DA Low

Physics in Medicine & Biology, vol. 63, pp. 04NT0420184 citations

Respiratory Motion

Animal Study

2017 (7 publications)

A generalized framework unifying image registration and respiratory motion models and incorporating image reconstruction, for partial image data or full images

JR McClelland, M Modat, S Arridge, H Grimes, D D'Souza, D Thomas, D O'Connell, DA Low, E Kaza, DJ Collins

Physics in Medicine & Biology, vol. 62, pp. 4273201766 citations

Image Registration

Respiratory Motion

Image Reconstruction

Feasibility evaluation of diffusion-weighted imaging using an integrated MRI-radiotherapy system for response assessment to neoadjuvant therapy in rectal cancer

N Shaverdian, Y Yang, P Hu, S Hart, K Sheng, J Lamb, M Cao, David Thomas, Y Gao, M Kamrava

The British journal of radiology, vol. 90, pp. 20160739201758 citations

Diffusion-weighted Imaging

MRI

Rectal Cancer

Dosimetric validation of a magnetic resonance image gated radiotherapy system using a motion phantom and radiochromic film

JM Lamb, JS Ginn, DP O'Connell, N Agazaryan, M Cao, David Thomas, Y Yang, DA Low, PP Lee

Journal of Applied Clinical Medical Physics, vol. 18, pp. 163-169201749 citations

MRI

Radiotherapy

Dosimetry

Adaptive weighted median filtering for reduced blurring when fusing co-registered fast helical CT images

D O'Connell, David Thomas, TH Dou, E Aliotta, JH Lewis, JM Lamb, P Lee, DA Low

Biomedical Physics & Engineering Express, vol. 3, pp. 06700220177 citations

Image Fusion

Filtering

Analysis of motion blurring artifact in fast helical free‐breathing thoracic CT scans

DA Low, L Yang, J Chen, D O'Connel, JH Lewis, David Thomas, P Lee

Medical Physics, vol. 44, pp. 1456-146120179 citations

Motion Artifact

Thoracic Imaging

Online Adaptive Radiation Therapy: Implementation of a New Process of Care

J Lamb, M Cao, A Kishan, N Agazaryan, David Thomas, N Shaverdian, Y Yang, S Ray, DA Low, JD Steinberg, PP Lee

Cureus, vol. 9, pp. e16182017138 citations

Adaptive Radiation Therapy

Process of Care

Implementation

Comparison of lung tumor motion measured using a model-based 4DCT technique and a commercial protocol

D O'Connell, N Shaverdian, AU Kishan, David Thomas, TH Dou, JH Lewis, DA Low, PP Lee

Practical Radiation Oncology201711 citations

Lung Tumor

Motion

4DCT

2016 (6 publications)

Longitudinal diffusion MRI for treatment response assessment: Preliminary experience using an MRI-guided tri-cobalt 60 radiotherapy system

Y Yang, M Cao, K Sheng, Y Gao, A Chen, M Kamrava, P Lee, David Thomas, DA Low, PP Hu

Medical physics, vol. 43, pp. 1369-13732016124 citations

Diffusion MRI

Treatment Response

Radiotherapy

Is there an ideal set of prospective scan acquisition phases for fast-helical based 4D-CT?

David Thomas, D Ruan, P Williams, J Lamb, BM White, T Dou, D O'Connell, JH Lewis, DA Low

Physics in Medicine & Biology, vol. 61, pp. N63220169 citations

4D-CT

Scan Acquisition

Fast-helical

Computerized triplet beam orientation optimization for MRI‐guided Co‐60 radiotherapy

D Nguyen, D Thomas, M Cao, D O'Connor, J Lamb, K Sheng

Medical physics, vol. 43, pp. 5667-5675201619 citations

Beam Orientation

Optimization

MRI-guided

Fast simulated annealing and adaptive Monte Carlo sampling based parameter optimization for dense optical-flow deformable image registration of 4DCT lung anatomy

TH Dou, Y Min, J Neylon, D Thomas, P Kupelian, AP Santhanam

Medical Imaging 2016: Image-Guided Procedures, Robotic Interventions, and Modeling, vol. 9786201611 citations

Parameter Optimization

Image Registration

4DCT

Intrafraction Organ Motion Tracking With Real-Time MRI-Guided Radiation Therapy for Head and Neck Cancer

JC Rwigema, David Thomas, M Cao, T Yoshizaki, AM Chen

International Journal of Radiation Oncology• Biology• Physics, vol. 94, pp. 87820162 citations

Organ Motion

MRI-guided

Head and Neck Cancer

Dosimetric effects of couch position variability on treatment plan quality with an MRI‐guided Co‐60 radiation therapy machine

PE Chow, David Thomas, N Agazaryan, M Cao, DA Low, Y Yang, JM Lamb

Medical physics, vol. 43, pp. 4514-451920161 citation

Couch Position

MRI-guided

Treatment Planning

2015 (5 publications)

A Method for Assessing Ground-Truth Accuracy of the 5DCT Technique

TH Dou, David Thomas, DP O'Connell, JM Lamb, P Lee, DA Low

International Journal of Radiation Oncology* Biology* Physics, vol. 93, pp. 925-933201534 citations

5DCT

Ground-Truth

Accuracy

5D respiratory motion model based image reconstruction algorithm for 4D cone-beam computed tomography

J Liu, X Zhang, X Zhang, H Zhao, Y Gao, D Thomas, DA Low, H Gao

Inverse Problems, vol. 31, pp. 115007201547 citations

Respiratory Motion

Image Reconstruction

CBCT

Comparison of breathing gated CT images generated using a 5DCT technique and a commercial clinical protocol in a porcine model

DP O'Connell, David Thomas, TH Dou, JM Lamb, F Feingold, DA Low, PP Lee

Medical physics, vol. 42, pp. 4033-4042201520 citations

Breathing Gated CT

5DCT

Porcine Model

Simulation of 4DCT tumor motion measurement errors

TH Dou, David Thomas, D O'Connell, JD Bradley, JM Lamb, DA Low

Medical physics, vol. 42, pp. 6084-6089201516 citations

4DCT

Tumor Motion

Simulation

Objective function to obtain multiple representative waveforms for a novel helical CT scan protocol

D Ruan, D Thomas, DA Low

Medical Physics, vol. 42, pp. 1164-116920157 citations

Helical CT

Waveforms

Scan Protocol

2014 (3 publications)

A Novel Fast Helical 4D-CT Acquisition Technique to Generate Low-Noise Sorting Artifact–Free Images at User-Selected Breathing Phases

D Thomas, J Lamb, B White, S Jani, S Gaudio, P Lee, D Ruan, M McNitt-Gray, DA Low

International Journal of Radiation Oncology* Biology* Physics, vol. 89, pp. 191-198201478 citations

4D-CT

Helical

Breathing Phases

Modeling and incorporating cardiac‐induced lung tissue motion in a breathing motion model

BM White, A Santhanam, D Thomas, Y Min, JM Lamb, J Neylon, S Jani, S Gaudio, S Srinivasan, D Ennis

Medical physics, vol. 41, pp. 04170120149 citations

Cardiac-induced Motion

Lung Tissue

Motion Model

Automatic dissociation between microvasculature and larger vessels for ultrasound contrast imaging

A Perperidis, D Thomas, M Averkiou, C Duncan, A McNeilly, M Butler, V Sboros

Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE, pp. 5076-507920148 citations

Ultrasound

Contrast Imaging

Microvasculature

2013 (4 publications)

A novel CT acquisition and analysis technique for breathing motion modeling

DA Low, BM White, PP Lee, David Thomas, S Gaudio, SS Jani, X Wu, D Lamb

Physics in Medicine & Biology, vol. 58, pp. L31201368 citations

Breathing Motion

Modeling

A Comparison of Amplitude-Based and Phase-Based Positron Emission Tomography Gating Algorithms for Segmentation of Internal Target Volumes of Tumors Subject to Respiratory Motion

SS Jani, CG Robinson, M Dahlbom, BM White, David Thomas, S Gaudio, DA Low, JD Bradley, JM Lamb

International Journal of Radiation Oncology* Biology* Physics, vol. 87, pp. 562-569201330 citations

PET

Gating

Respiratory Motion

Microbubble oscillations in capillary tubes

David Thomas, V Sboros, M Emmer, H Vos, N De Jong

IEEE transactions on ultrasonics, ferroelectrics, and frequency control, vol. 60, pp. 105-114201341 citations

Microbubble

Oscillations

Capillary Tubes

The acoustic signature of decaying resonant phospholipid microbubbles

David Thomas, M Butler, N Pelekasis, T Anderson, E Stride, V Sboros

Physics in Medicine & Biology, vol. 58, pp. 589201312 citations

Acoustic

Microbubbles

Phospholipid

2012 (1 publications)

The "quasi-stable" lipid shelled microbubble in response to consecutive ultrasound pulses

David Thomas, M Butler, T Anderson, M Emmer, H Vos, M Borden, E Stride, N de Jong, V Sboros

Applied Physics Letters, vol. 101, pp. 071601201233 citations

Lipid

Microbubble

Ultrasound

2011 (2 publications)

Imaging of the ovine corpus luteum microcirculation with contrast ultrasound

V Sboros, M Averkiou, M Lampaskis, David Thomas, N Silva, C Strouthos, CM Loizou, CL Pitsillides

Ultrasound in Medicine and Biology, vol. 37, pp. 59-68201124 citations

Ultrasound

Contrast

Microcirculation

On the acoustic response of microbubbles in arteriole sized vessels

MB Butler, David Thomas, N Silva, SD Pye, V Sboros

Applied Physics Letters, vol. 99, pp. 19370220119 citations

Acoustic

Microbubbles

Vessels

2010 (3 publications)

The acoustic scatter from single bisphere microbubbles

David Thomas, MB Butler, A Dermitzakis, T Anderson, WN McDicken, V Sboros

Ultrasound in Medicine and Biology, vol. 36, pp. 1884-189220109 citations

Acoustic

Microbubbles

Scatter

Acoustic Investigation of Microbubble Response to Medical Imaging Ultrasound Pulses

David Thomas

The University of Edinburgh20103 citations

Acoustic

Microbubbles

Ultrasound

Single microbubble acoustics in small tubes

MB Butler, A Dermitzakis, D Thomas, P Looney, S Pye, V Sboros

Proc. Int. Conf. Acoustics20103 citations

Microbubble

Acoustics

Tubes

2009 (4 publications)

Acoustic detection of microbubble resonance

David Thomas, P Looney, R Steel, N Pelekasis, WN McDicken, T Anderson, V Sboros

Applied Physics Letters, vol. 94, pp. 243902200937 citations

Acoustic

Microbubble

Resonance

Single microbubble response using pulse sequences: initial results

David Thomas, MB Butler, T Anderson, R Steel, SD Pye, M Poland, T Brock-Fisher, WN McDicken, V Sboros

Ultrasound in Medicine and Biology, vol. 35, pp. 112-119200926 citations

Microbubble

Pulse Sequences

Response

Optical observations of microbubble oscillation in small tubes

D Thomas, V Sboros, M Emmer, HJ Vos, N de Jong

Ultrasonics Symposium (IUS), 2009 IEEE International, pp. 2782-278420094 citations

Optical

Microbubble

Oscillation

Survival of single microbubbles insonated in solution and in narrow tubes

M Butler, A Dermitzakis, D Thomas, SD Pye, V Sboros

Ultrasonics Symposium (IUS), 2009 IEEE International, pp. 1259-126120093 citations

Microbubble

Survival

Tubes

2008 (3 publications)

The acoustic response from individual attached and unattached rigid shelled microbubbles

MB Butler, David Thomas, SD Pye, CM Moran, WN McDicken, V Sboros

Applied Physics Letters, vol. 93, pp. 223906200812 citations

Acoustic

Microbubbles

Rigid Shelled

A realistic model for ultrasound contrast microbubbles: initial results

P Looney, D Thomas, R Steel, T Anderson, N Pelekasis, V Sboros

WIMRC Cavitation Forum, pp. 157-16420083 citations

Ultrasound

Contrast

Microbubbles

Comparison of the acoustic response of attached and unattached BiSphere™ microbubbles

MB Butler, David Thomas, CM Moran, WN McDicken, V Sboros, SD Pye

Ultrasonics Symposium, 2008. IUS 2008. IEEE, pp. 1683-168520082 citations

Acoustic

Microbubbles

BiSphere

2007 (1 publications)

Single Microbubble Acoustics with Signal Processing: Initial Experience with Amplitude Modulated Pulse Sequences

David Thomas, MB Butler, T Anderson, WN McDicken, V Sboros

Ultrasonics Symposium, 2007. IEEE, pp. 2223-222620074 citations

Microbubble

Acoustics

Signal Processing

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