David Thomas

Associate Professor


Curriculum vitae



720-848-0134


Department of Radiation Oncology

University of Colorado Anschutz Medical Campus

Department of Radiation Oncology – University of Colorado Denver | Anschutz Medical Campus
1665 Aurora Court, Suite 1032
Mail Stop F706
Aurora, CO 80045



Quantitative assessment and prediction of breathing motion for radiation therapy


Initial clinical observations of intra-and interfractional motion variation in MR-guided lung SBRT, DOI: 10.1259/bjr.20170522
Initial clinical observations of intra-and interfractional motion variation in MR-guided lung SBRT, DOI: 10.1259/bjr.20170522
Real Time Dose Calculation of MRI Guided Co-60 Radiotherapy Treatments On Free Breathing Patients.  DOI: 10.1118/1.4925244
Real Time Dose Calculation of MRI Guided Co-60 Radiotherapy Treatments On Free Breathing Patients. DOI: 10.1118/1.4925244
My research at UCLA focused on developing techniques for radiotherapy treatment planning that explicitly consider and compensate for breathing motion. Intra-fraction motion remains one of the biggest challenges in radiation therapy. In most cases, radiation therapy treatment plans are static; they contain no intrinsic motion information aside from simplified surrogates for complex tumor motion signatures. Intra-fraction motion is typically managed during the treatment planning process by adjusting the treatment plan so that the tumor either never or rarely leaves the high dose region. By far the most impactful source of intra-fraction motion is breathing induced motion. In my work at UCLA, I took the lead on developing the next generation of 4D-CT imaging for improved management of motion during radiotherapy treatment planning and delivery, a technique that is now used clinically

Publications


A prospective gating method to acquire a diverse set of free-breathing CT images for model-based 4DCT


Dylan O'Connell, Dan Ruan, David H Thomas, Tai H Dou, John H Lewis, Anand P Santhanam, Percy P Lee, Daniel A Low

Physics in Medicine and Biology, 2018


A generalized framework unifying image registration and respiratory motion models and incorporating image reconstruction, for partial image data or full images


J. R. McClelland, M. Modat, S. Arridge, H. Grimes, D. D'Souza, D. H. Thomas, D. O. Connell, D. A. Low, E. Kaza, D. J. Collins, M. O. Leach, D. J. Hawkes

Phys Med Biol, vol. 62, 2017, pp. 4273-4292


Technical Note: Simulation of 4DCT Tumor Motion Measurement Errors


T H Dou, D H Thomas, D O�Connell, J Bradley, D A Low

Medical physics, vol. 42, American Association of Physicists in Medicine, 2015, p. 6084


A Method for Assessing Ground-Truth Accuracy of the 5DCT Technique


T H Dou, D H Thomas, D H O�Connell, J M Lamb, P Lee, D A Low

International Journal of Radiation Oncology* Biology* Physics, vol. 93, American Association of Physicists in Medicine, 2015, pp. 925--933


TH-CD-303-04: A Method for Assessing Ground-Truth Accuracy of a Motion Model Based 4DCT Technique


T Dou, D H Thomas, D O�Connell, J Lamb, D Low

Medical physics, vol. 42, American Association of Physicists in Medicine, 2015, pp. 3729--3729


5D respiratory motion model based image reconstruction algorithm for 4D cone-beam computed tomography


Jiulong Liu, Xue Zhang, Xiaoqun Zhang, Hongkai Zhao, Yu Gao, DH Thomas, Daniel Low, Hao Gao

Inverse Problems, vol. 31, IOP, 2015, p. 115007


SU-EJ-234: Application of a Breathing Motion Model to ViewRay Cine MR Images


D P O�Connell, D H Thomas, T H Dou, J M Lamb, L Yang, D A Low

Medical physics, vol. 42, American Association of Physicists in Medicine, 2015, pp. 3319--3319


SU-C-BRA-05: Fast Generation of Respiratory Gated CT Images at User Selected Breathing Phases On a Graphics Processing Unit


D P O�Connell, D H Thomas, TH Dou, J M Lamb, L Yang, D A Low

Medical physics, vol. 42, American Association of Physicists in Medicine, 2015, pp. 3196--3196


Comparison of breathing gated CT images generated using a 5DCT technique and a commercial clinical protocol in a porcine model


Dylan P O�Connell, D H Thomas, Tai H Dou, James M Lamb, Franklin Feingold, Daniel A Low, Matthew K Fuld, Jered P Sieren, Chelsea M Sloan, Melissa A Shirk, others

Medical physics, vol. 42, American Association of Physicists in Medicine, 2015, pp. 4033--4042


Objective function to obtain multiple representative waveforms for a novel helical CT scan protocol


Dan Ruan, D H Thomas, Daniel A Low

Medical Physics, vol. 42, American Association of Physicists in Medicine, 2015, pp. 1164--1169


SU-F-303-17: Real Time Dose Calculation of MRI Guided Co-60 Radiotherapy Treatments On Free Breathing Patients, Using a Motion Model and Fast Monte Carlo Dose Calculation


D H Thomas, D O�Connell, J Lamb, M Cao, Y Yang, N Agazaryan, P Lee, D Low

Medical physics, vol. 42, American Association of Physicists in Medicine, 2015, pp. 3541--3541


TH-CD-204-06: Diffusion MRI for Treatment Response Assessment of MRI-Guided Tri-Cobalt 60 Radiotherapy


Y Yang, D Low, M Cao, K Sheng, J Lamb, D H Thomas, M Kamrava, P Hu

Medical physics, vol. 42, American Association of Physicists in Medicine, 2015, pp. 3733--3733


SU-D-17A-03: 5D Respiratory Motion Model Based Iterative Reconstruction Method for 4D Cone-Beam CT


Y Gao, D H Thomas, D Low, H Gao

Medical Physics, vol. 41, American Association of Physicists in Medicine, 2014, pp. 117--117


A Novel Fast Helical 4D-CT Acquisition Technique to Generate Low-Noise Sorting Artifact--Free Images at User-Selected Breathing Phases


D H Thomas, James Lamb, Benjamin White, Shyam Jani, Sergio Gaudio, Percy Lee, Dan Ruan, Michael McNitt-Gray, Daniel Low

International Journal of Radiation Oncology* Biology* Physics, vol. 89, Elsevier, 2014, pp. 191--198


TH-C-18A-11: Investigating the Minimum Scan Parameters Required to Generate Free-Breathing Fast-Helical CT Scans Without Motion-Artifacts


D H Thomas, J Tan, J Neylon, T Dou, S Jani, J Lamb, D Low

Medical Physics, vol. 41, American Association of Physicists in Medicine, 2014, pp. 559--559


Modeling and incorporating cardiac?induced lung tissue motion in a breathing motion model


Benjamin M White, Anand Santhanam, David Thomas, Yugang Min, James M Lamb, Jack Neylon, Shyam Jani, Sergio Gaudio, Subashini Srinivasan, Daniel Ennis

Medical physics, vol. 41, 2014


SU-E-J-126: Development of a Prospective Gating Algorithm for a Novel 4DCT Technique: Retrospective Data Analysis


D Low, D H Thomas, B White, S Gaudio, S Jani, P Lee, J Lamb

Medical Physics, vol. 40, American Association of Physicists in Medicine, 2013, pp. 179--179


Share



Follow this website


You need to create an Owlstown account to follow this website.


Sign up

Already an Owlstown member?

Log in